diff --git a/e2e/go.mod b/e2e/go.mod
index f0a5e9fb7d..51a333d322 100644
--- a/e2e/go.mod
+++ b/e2e/go.mod
@@ -23,7 +23,7 @@ require (
 	github.com/Microsoft/go-winio v0.6.2 // indirect
 	github.com/agnivade/levenshtein v1.2.1 // indirect
 	github.com/beorn7/perks v1.0.1 // indirect
-	github.com/bytecodealliance/wasmtime-go/v39 v39.0.1 // indirect
+	github.com/bytecodealliance/wasmtime-go/v43 v43.0.2 // indirect
 	github.com/cenkalti/backoff/v4 v4.3.0 // indirect
 	github.com/cenkalti/backoff/v5 v5.0.3 // indirect
 	github.com/cespare/xxhash/v2 v2.3.0 // indirect
diff --git a/go.mod b/go.mod
index c7fc91a8b5..21e21fe36d 100644
--- a/go.mod
+++ b/go.mod
@@ -4,7 +4,7 @@ go 1.25.0
 
 require (
 	github.com/agnivade/levenshtein v1.2.1
-	github.com/bytecodealliance/wasmtime-go/v39 v39.0.1
+	github.com/bytecodealliance/wasmtime-go/v43 v43.0.2
 	github.com/cespare/xxhash/v2 v2.3.0
 	github.com/containerd/containerd/v2 v2.2.2
 	github.com/containerd/errdefs v1.0.0
diff --git a/go.sum b/go.sum
index 4606cbbf9b..8ddc9f1caf 100644
--- a/go.sum
+++ b/go.sum
@@ -8,8 +8,8 @@ github.com/arbovm/levenshtein v0.0.0-20160628152529-48b4e1c0c4d0 h1:jfIu9sQUG6Ig
 github.com/arbovm/levenshtein v0.0.0-20160628152529-48b4e1c0c4d0/go.mod h1:t2tdKJDJF9BV14lnkjHmOQgcvEKgtqs5a1N3LNdJhGE=
 github.com/beorn7/perks v1.0.1 h1:VlbKKnNfV8bJzeqoa4cOKqO6bYr3WgKZxO8Z16+hsOM=
 github.com/beorn7/perks v1.0.1/go.mod h1:G2ZrVWU2WbWT9wwq4/hrbKbnv/1ERSJQ0ibhJ6rlkpw=
-github.com/bytecodealliance/wasmtime-go/v39 v39.0.1 h1:RibaT47yiyCRxMOj/l2cvL8cWiWBSqDXHyqsa9sGcCE=
-github.com/bytecodealliance/wasmtime-go/v39 v39.0.1/go.mod h1:miR4NYIEBXeDNamZIzpskhJ0z/p8al+lwMWylQ/ZJb4=
+github.com/bytecodealliance/wasmtime-go/v43 v43.0.2 h1:EZJlEpDanv6j/Y5Mcl2ndMjgK5Tw2QVDTJCzmLWNozg=
+github.com/bytecodealliance/wasmtime-go/v43 v43.0.2/go.mod h1:EhGDFKNmDpLc6l4Cq+U2y8zu3NM6Uiek+He4yebZFHs=
 github.com/cenkalti/backoff/v5 v5.0.3 h1:ZN+IMa753KfX5hd8vVaMixjnqRZ3y8CuJKRKj1xcsSM=
 github.com/cenkalti/backoff/v5 v5.0.3/go.mod h1:rkhZdG3JZukswDf7f0cwqPNk4K0sa+F97BxZthm/crw=
 github.com/cespare/xxhash/v2 v2.3.0 h1:UL815xU9SqsFlibzuggzjXhog7bL6oX9BbNZnL2UFvs=
diff --git a/internal/wasm/sdk/internal/wasm/bindings.go b/internal/wasm/sdk/internal/wasm/bindings.go
index 90e149fde7..9b61cb52a5 100644
--- a/internal/wasm/sdk/internal/wasm/bindings.go
+++ b/internal/wasm/sdk/internal/wasm/bindings.go
@@ -16,7 +16,7 @@ import (
 	"strconv"
 	"time"
 
-	wasmtime "github.com/bytecodealliance/wasmtime-go/v39"
+	wasmtime "github.com/bytecodealliance/wasmtime-go/v43"
 
 	"github.com/open-policy-agent/opa/v1/ast"
 	"github.com/open-policy-agent/opa/v1/metrics"
diff --git a/internal/wasm/sdk/internal/wasm/pool.go b/internal/wasm/sdk/internal/wasm/pool.go
index 0228425ca5..8834a32b97 100644
--- a/internal/wasm/sdk/internal/wasm/pool.go
+++ b/internal/wasm/sdk/internal/wasm/pool.go
@@ -9,7 +9,7 @@ import (
 	"context"
 	"sync"
 
-	wasmtime "github.com/bytecodealliance/wasmtime-go/v39"
+	wasmtime "github.com/bytecodealliance/wasmtime-go/v43"
 
 	"github.com/open-policy-agent/opa/internal/wasm/sdk/opa/errors"
 	"github.com/open-policy-agent/opa/internal/wasm/util"
diff --git a/internal/wasm/sdk/internal/wasm/vm.go b/internal/wasm/sdk/internal/wasm/vm.go
index 7326bc3fe3..2218974911 100644
--- a/internal/wasm/sdk/internal/wasm/vm.go
+++ b/internal/wasm/sdk/internal/wasm/vm.go
@@ -14,7 +14,7 @@ import (
 	"strings"
 	"time"
 
-	wasmtime "github.com/bytecodealliance/wasmtime-go/v39"
+	wasmtime "github.com/bytecodealliance/wasmtime-go/v43"
 
 	sdk_errors "github.com/open-policy-agent/opa/internal/wasm/sdk/opa/errors"
 	"github.com/open-policy-agent/opa/internal/wasm/util"